Trajectories of Outcome in Neurological Conditions (TONiC)

Trajectories of Outcome in Neurological Conditions (TONiC)

TONiC is a national study examining the factors that influence quality of life in people with neurological conditions. It is the largest study of its kind ever performed in the world.

So far, about one in four people with motor neuron disease (MND) living in the UK have joined TONiC. The more people join and contribute their experiences and view points, the more powerful the results.

The results from TONiC will be used to improve services by identifying aspects of MND that are important to people living with MND, but which might be underestimated by current service provision. As part of TONiC we will develop 'outcome measures' that can be used for future studies.

People with MND at any stage of their illness are welcome to participate, the 'tick box' questionnaires are easily done at home at your own pace. If you cannot write, someone can tick your chosen response on your behalf. 

To take part, contact the local TONiC champion at a centre near you.

Visit the TONiC website

Contact the study team direct: +44 151 529 5668/2980 or e-mail

UK Chief Investigator

Professor Carolyn Young

Research summary

Quality of life (QoL) for people with disabling neurological conditions is affected by a range of factors, which have received considerable previous research attention. However, clinicians' knowledge could be enhanced by two areas of additional enquiry.

1. Wide consultation

Such analysis would have greater validity than that used previously as it would reflect a wide range of patient and clinician opinion.

2. Testing factors for QoL influence

Data would be analysed using statistical techniques to determine the nature and strength of relations between different factors.

The researchers will develop and test models of factors affecting QoL and compare whether models vary between conditions.

The model structure reflects World Health Organisation impairment, activity, and participation areas. The benefit of this approach is that we are testing factors which reflect concerns of people experienced in the conditions, to develop a model which may assist interventions to improve quality of life.

Inclusion / exclusion criteria

Inclusion criteria

Exclusion criteria

Current status

Active – Recruiting


Sites recruiting MND patients:





Information about study sites

Contact details

Coordinating centre telephone: 0151 529 5668 / 0151 529 2980


Recruitment groups

Patients with neurological conditions

Recruitment targets

16,500 patients nationally (this includes patients with MND and patients with other neurological conditions).

Key dates

Recruitment start date: 1 June 2012

Planned recruitment end date: 30 June 2027.


Walton Centre for Neurology and Neurosurgery NHS Foundation Trust

Study design

Longitudinal, observational (questionnaire).

Intervention (if applicable)

Not applicable

Phase (if applicable)

Not applicable

Outcome measures

Publications / Results reports

Lay summary of published papers

Published papers

Platform presentations