Study Progress Information

You can find information below regarding the current recruitment status for MND studies and clinical trials that are taking place across the UK.

If you have taken part in a study, you may be interested to find out more about the progress of the study or view the study results.  Please be aware that some studies are global in scale and can take place over a long timeframe. Because of this, the results may not be published until some time after your participation has ended. Once studies have closed to recruitment, they move to this section of the website. We are working with researchers to encourage them to share the findings of their research studies as soon as they are available, and collating the information we receive on the Closed studies page here.

We aim to update the information on this page on a monthly basis.

Study TitleCurrent UK recruitment (last updated 01Nov2021) / UK Recruitment targetPlanned UK Recruitment End DateCurrent Study StatusStudy Website / Publications
AMBRoSIA760 / 585 (130% recruitment target achieved)14/12/2021Active, recruitingAMBRoSIA
ALS Biomarkers Study1208 / 1500 (81% recruitment target achieved)31/12/2025Active, recruitingALS Biomarkers Study
ALSFRS-R Online Validation
187 / 100 (187% recruitment target achieved)01/02/2021Active, recruitingALSFRS-R Online Validation Study
COMMEND RCT
111 / 188 (59% recruitment target achieved)31/05/2022Active, recruitingCOMMEND randomised controlled trial
C9orf72 Cohort Study102 / 90 (113% recruitment target achieved)30/06/2022Active, recruitingC9orf72 Cohort Study
DiAMoND Study: Phase 30 / 170 (0% recruitment target achieved)31/12/2021Active, recruiting
Measuring Cognitive and Behavioural Change in ALS
247 / 305 (81% recruitment target achieved)30/06/2021Active, recruitingMeasuring Cognitive and Behavioural Change in ALS
Apellis phase 2 Pegcetacoplan trial (MERIDIAN)
0 / 15 (0% recruitment target achieved)01/08/2021Active, recruiting
MIND-MAPS-ALS
0 / 16 (0% recruitment target achieved)01/01/2023Active, recruiting
MiNDToolkit Feasibility Study
0 / 20 (0% recruitment target achieved)31/05/2022Active, recruitingMiNDToolkit Feasibility Study
MND Register
2696 / 950 (284% recruitment target achieved)31/12/2021Active, recruitingMND Register
MND-SMART
208 / 750 (28% recruitment target achieved)02/11/2026Active, recruitingMND-SMART
Motor System Genomics
1109 / 2000 (55% recruitment target achieved)30/09/2022Active, recruitingMotor System Genomics
Neuro Digital: Outpatient Perspectives Study
0 / 64 (0% recruitment target achieved)28/01/2022Active, recruiting
Novel Electrical Impedance Spectroscopy for Neurological disorders
56 / 175 (32% recruitment target achieved)31/03/2022Active, recruitingNovel Electrical Impedance Spectroscopy
OptiCALS Randomised Controlled Trial
13 / 334 (4% recruitment target achieved)02/11/2022Active, recruiting
PostGas
153 / 200 (77% recruitment target achieved)28/02/2022Active, recruitingPostGas
Remote surface EMG in MND
4 / 6 (67% recruitment target achieved)03/03/2022Active, recruiting
RHAPSODY Speech-based biomarkers Pilot Study
38 / 250 (15% recruitment target achieved)01/11/2021Active, recruiting
Focus-C9 (Wave) phase 1 trial
1 / 22 (5% recruitment target achieved)09/04/2023Active, recruiting
TONiCPhase 2: 12,203 / 11,700 (104% recruitment target achieved)
Phase 3: 16,187 / 16,500 (98% recruitment target achieved)
Phases 4 & 5: 3,446 / 1,500 (230% recruitment target achieved)
30/11/2020Active, recruitingTrajectories of Outcome in Neurological Conditions (TONiC)
TUDCA-ALS
46 / 70 (66% recruitment target achieved)30/06/2021Active, recruitingTUDCA-ALS trial