Studies closed to recruitment

Links to studies that have closed to recruitment can be found below. Click on the study title for further details:

Study titleDate closed to recruitmentCurrent status
BioMOx: BioMOx: The Oxford Study for Biomarkers in Motor Neuron Disease2018-12-31• Data being analysed;
• Manuscript in preparation;
• Results published (links to papers provided).
Tongue EIM: Developing electrical impedance myography of the tongue for motor system disorders2018-07-31Closed to Recruitment, In Follow Up
Biogen Methodology study: Methodology Study of Novel Outcome Measures to Assess Progression of ALS2017-05-31Analysis
ALS/FTD study: Is ALS/FTD Neuropsychologically distinct from FTD?2017-10-15Closed to Recruitment, No Follow Up
CALL-Me: Assessment of care augmentation by location-linked messaging in amyotrophic lateral sclerosis with respiratory impairment compared with current standard care2019-02-07Closed to Recruitment, In Follow Up
OPTCARE Neuro: Evaluation of the clinical and cost­ effectiveness of Short-­term Integrated Palliative Care Services (SIPC) to OPTimise CARE for people with advanced long­term Neurological conditions (OPTCARE Neuro)2017-11-10Closed to Recruitment, In Follow Up
ALSCarE: A Programme for ALS Care in Europe (ALSCarE)2017-08-04Closed to Recruitment, In Follow Up
EncoreAnywhere: Monitoring and promoting adherence to non-invasive ventilation in motor neurone disease using EncoreAnywhere telemonitoring2017-04-01Closed to Recruitment, In Follow Up
CSNAT: Enabling tailored and coordinated support for family carers of people with Motor Neurone Disease (MND) through adaptation of a Carer Support Needs Assessment Tool (CSNAT) Intervention2019-06-17Closed to Recruitment, no follow up
COMMEND feasibility study: A feasibility study of acceptance and COMmitment therapy for people with Motor nEuroN Disease (COMMEND)2018-11-30Closed to Recruitment, In Follow Up
Using MRI to investigate energy metabolism: Using MRI to investigate energy metabolismClosed to Recruitment, no follow up
MIROCALS: Efficacy and safety of low-dose IL-2 (ld-IL-2) as a Treg enhancer for controlling neuro-inflammation in newly diagnosed Amyotrophic Lateral Sclerosis (ALS) patients: A randomized, double-blind, placebo- controlled, phase-II Proof of Concept/ Proof of Mechanism Clinical Trial2019-11-04Closed to Recruitment, In Follow Up
ProSec3: 2020-08-30Data being analysed
MIND-MAPS-ALS: Molecular Imaging of Neurodegenerative Disease – Mitochondria, Associated Proteins & Synapses – Amyotrophic Lateral Sclerosis (MIND-MAP-ALS)2020-03-19Closed to Recruitment, In Follow Up
HighCALS intervention development study: A qualitative study to develop, refine and assess the acceptability of a complex intervention to increase nutritional intake in people with Amyotrophic Lateral Sclerosis.2020-09-30Closed to Recruitment, In Follow Up
ILB phase 2 trial: A phase II study to determine the safety and tolerability of ILB , a type of low molecular weight dextran sulfate, in patients with Motor Neurone Disease (MND)/ Amyotrophic Lateral Sclerosis (ALS)2020-10-12Closed to Recruitment, In Follow Up
REVEALS Respiratory Registry: The overall aim of this study is to identify the most appropriate outcome measures to detect meaningful clinical differences in breathing and cough muscle strength which can be used in future studies to evaluate the effectiveness of new treatments.2021-04-28Closed to Recruitment
Alexion Champion ALS study: A Phase-3, Double-Blind, Randomized, Placebo-Controlled, Parallel Group, Multicentre Study With an Open-Label Extension to Evaluate the Efficacy and Safety of Ravulizumab in Patients With Amyotrophic Lateral Sclerosis (ALS).2021-04-21Closed to Recruitment
Biogen SOD1: A Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB067 Administered to Adult Subjects with Amyotrophic Lateral Sclerosis (ALS) and Confirmed Superoxide Dismutase 1 Mutation.
2020-11-30Closed to Recruitment
TUDCA-ALS: The aim of the study is to determine whether TUDCA has an impact on the progression of ALS.Closed to Recruitment
Biogen C9orf72: A Phase 1 Multiple-Ascending-Dose Study to Assess the Safety, Tolerability, and Pharmacokinetics of BIIB078 Administered Intrathecally to Adults with C9ORF72-Associated Amyotrophic Lateral Sclerosis.2021-05-26Closed to Recruitment
DiAMoND study: The aim of this study is to develop and pilot a web-based decision aid to support individuals with motor neurone disease (MND) choose whether to have a gastrostomy feeding tube.2021-10-04Closed to Recruitment
NRF2 Biomarkers Study: This study aims to assess techniques for measuring glutathione levels in the central nervous system of MND patients and controls using MRI, and also in CSF and blood samples. It may then be possible to use these techniques in future trials of NRF2-activating drugs to assess how well they work in the body.2021-06-07Closed to Recruitment
Measuring Cognitive and Behavioural Change in ALS: Cognitive and behavioural impairment in Amyotrophic Lateral Sclerosis: Comparing measures and validating revised consensus diagnostic criteria for Amyotrophic Lateral Sclerosis-Frontotemporal Spectrum Disorder2021-06-30Closed to Recruitment