Kevin Talbot qualified in medicine from the University of London and trained in Neurology in London and Oxford. His doctoral research was on the childhood motor neuron disorder spinal muscular atrophy (SMA) in the laboratory of Professor Kay Davies. He subsequently became Clinical Lecturer in Neurology and from 2001-2006 held an MRC Clinician Scientist Fellowship. In 2010 he became Professor of Motor Neuron Biology, and in 2015 he was appointed Head of the Division of Clinical Neurology in the Nuffield Department of Clinical Neurosciences, University of Oxford. He currently co-directs the Oxford MND Care and Research Centre, a multidisciplinary team providing a clinical service for patients with motor neuron disorders, from all over the South of England.
Professor Talbot’s research is focussed on in vitro and in vivo modelling of the earliest phases of ALS pathogenesis, to elucidate the basic mechanisms of motor neuron degeneration and accelerate the identification of disease modifying treatments. His team have created spinal motor and cortical neuronal models bases on induced pluripotent stem cells, and novel BAC-transgenic mice carrying TDP-43 or FUS mutations. Current work is focussed using these models to identify drug targets using high and medium throughput screening. He also actively participates in therapeutic trials in MND and in clinical studies to improve management of MND.